The object of research is the biological resistance of twenty-two samples of asphalt concrete with different bitumen content. Method. Laboratory testing of samples of asphalt concrete mixtures for fungal resistance and the presence of antifungal properties. Determination of changes in strength and elastic-plastic properties of materials. Results. Based on the conducted studies of biostability and the proposed methods for monitoring changes in hardness and modulus of deformation, the most preferable compositions were deter-mined with respect to their resistance to the effects of filamentous fungi. For each group of samples and mixtures of bitumen concrete under study, their ranking according to the degree of the resistance to the effects of the external microbiological medium is provided.